Anthropic Has a $65 Billion Run Rate. Buy These Stocks to Profit From It.

Anthropic, the owner and operator of the popular Claude chatbot, has an annualized revenue run rate of $65 billion, multiple media outlets just confirmed. That's about seven times what it was at the end of last year.

The company has filed with the Securities and Exchange Commission to go public later this year through an initial public offering (IPO) that could value it at $2 trillion or more. But because the AI firm is not yet public, there aren't many ways for retail investors to buy a direct stake in it.

There is an indirect way to get some exposure to Anthropic, however. That's by owning the stocks of companies that have invested heavily in its pre-IPO shares.

Image source: Getty Images.

That group starts with Amazon (NASDAQ: AMZN). The company's $33 billion investment in Anthropic gave it an impressive 21% stake. Google's parent company, Alphabet (NASDAQ: GOOGL) (NASDAQ: GOOG), holds a 15% stake in Anthropic and can't invest more because the two are major competitors in the large language model space. (Alphabet owns Gemini AI). Salesforce (NYSE: CRM) has a $5 billion stake in the AI firm. Finally, Zoom Communications (NASDAQ: ZM) has a more modest $1.3 billion stake in it.

Like everything else those companies own, their stakes in Anthropic are ultimately owned by their shareholders. So their investors should see a major benefit if Anthropic's IPO brings it a valuation of $2 trillion or more.

Several tech firms booked big gains from their SpaceX stakes

There's a recent precedent for this. In the second quarter of this year, two major technology firms had the biggest positive impact on overall S&P 500 earnings due to their stakes in other firms. Alphabet reported earnings per share of $9.11, more than three times Wall Street's expectations, driven by $98 billion in unrealized stock gains primarily from its ownership stake in Space Exploration Technologies (NASDAQ: SPCX), which went public that quarter.

Similarly, Amazon reported $53.4 billion in income from a revaluation of its investment in Anthropic (pre-IPO companies are officially revalued during each new capital-raising round). Amazon shares soared following the release of its second-quarter results. If Anthropic stages a blockbuster IPO, that investment would be revalued significantly higher again.

Neither Amazon nor Alphabet shares have had a particularly great 2026, however. After soaring in 2025, both stocks have delivered much more modest gains this year, mostly due to investors' concerns that their massive investments in AI infrastructure will not produce significant returns on investment. Salesforce's share price is down 22% year to date, as investors fear that AI tools could render the company's software obsolete.

It's not clear what the future holds for any of these companies, of course. AI technologies are already proving to be a seriously disruptive force -- both positive and negative -- for many industries.

Matthew Benjamin has positions in Alphabet. The Motley Fool has positions in and recommends Alphabet, Amazon, Salesforce, and Zoom Communications. The Motley Fool has a disclosure policy.