Down 55%, Should You Buy the Dip on Pfizer?

Source The Motley Fool

Key Points

  • Pfizer is a $145 billion pharmaceutical industry giant with a long history of success behind it.

  • Wall Street bid the stock up during the COVID-19 pandemic, but now investors have soured on the shares.

  • Pfizer is demonstrating that it can and will take the necessary steps to survive.

  • 10 stocks we like better than Pfizer ›

The last five or six years have been a roller-coaster ride for Pfizer (NYSE: PFE) and its shareholders. It was a fun ride on the way up, but after peaking in late 2021, the pharmaceutical giant's stock price has plunged. It is now down more than 55% from its 2021 high-water mark. This could be a buying opportunity for some long-term investors, but there's a caveat here that might dissuade one particular type of investor from jumping on board.

Pfizer is a drug industry survivor

There are numerous small pharmaceutical companies worldwide. There is only a handful of large ones. It is fairly common for small pharma companies with promising drug pipelines to be acquired by the industry's giants. Pfizer is one of the giants, boasting a $145 billion market cap despite the stock having lost more than half its value. Pfizer knows how to survive.

Where to invest $1,000 right now? Our analyst team just revealed what they believe are the 10 best stocks to buy right now. Continue »

A doctor talking to a smiling parent and child in a medical setting.

Image source: Getty Images.

What's notable is that the pharmaceutical industry is a highly competitive one that faces stringent regulations and requires substantial capital investment, as well as high research and development costs. Finding new drug candidates, proving their efficacy, getting them cleared for human use, and then selling them are much bigger tasks than they might sound. This is why companies that bring out new drugs are given a period of time in which they are the exclusive seller of those drugs.

There's one small problem: When a new drug's patent period ends, the revenue it generates tends to fall materially. That's what's known as a patent cliff. Patent cliffs are a common occurrence in the drug industry, and Pfizer is approaching one in 2027 and 2028 when the patents on Ibrance, Eliquis, and Vyndaqel are set to expire. The good news is that Pfizer's history suggests it will find a way to survive and thrive in the long term.

Why the dramatic ups and downs?

Part of the reason why Pfizer's price has been so volatile since 2020 is related to investor emotions. During the pandemic period, Wall Street was overly enamored of any drug company that had a COVID-19 vaccine to offer. So Pfizer, one of the vaccine makers, saw its stock rocket higher. Investors started to move away from the stock when the world learned to live with COVID-19. And then the realities of the upcoming patent cliff become even more prominent. The stock is currently trading below its level at the start of 2020.

That's not necessarily an unrealistic price, but the stock's price-to-sales, price-to-cash flow, and price-to-book value are all below their five-year averages. The only traditional valuation metric above the five-year average is price-to-earnings. If you think in decades and prefer value-oriented stocks, Pfizer could be a solid selection for your portfolio.

That's highlighted by the company's aggressive pursuit of Metsera (NASDAQ: MTSR). After agreeing to a deal, Metsera came up with another bidder, forcing Pfizer to up its offer. The fact that Pfizer can compete effectively to make acquisitions like this clearly shows that it will do what's necessary to survive.

The problem with Pfizer

If you are looking at Pfizer as a drug stock that is out of favor but likely to overcome its drug cliff issues, you might want to consider buying it. However, the current 100% dividend payout ratio suggests that dividend investors should be cautious. When the company acquired Wyeth in 2009, the board of directors cut the dividend.

Wyeth was a bigger deal, but with Pfizer's payout ratio so high, there isn't much wiggle room for the dividend. In other words, despite the attractive 6.6% yield, it is probably better to view Pfizer as a turnaround stock than a dividend stock. If the dividend survives, it will be icing on the cake.

Should you invest $1,000 in Pfizer right now?

Before you buy stock in Pfizer, consider this:

The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Pfizer wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years.

Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you’d have $599,784!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you’d have $1,165,716!*

Now, it’s worth noting Stock Advisor’s total average return is 1,035% — a market-crushing outperformance compared to 191% for the S&P 500. Don’t miss out on the latest top 10 list, available when you join Stock Advisor.

See the 10 stocks »

*Stock Advisor returns as of November 10, 2025

Reuben Gregg Brewer has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Pfizer. The Motley Fool has a disclosure policy.

Disclaimer: For information purposes only. Past performance is not indicative of future results.
placeholder
Ethereum slides 5% as bears lean on $3,500 cap and put $3,150 support in focusEthereum (ETH) drops more than 5% after a failed push above $3,550, with price sliding to $3,153 and now holding below $3,350, the 100-hour SMA and a bearish trend line at $3,500; unless bulls reclaim the $3,350–$3,500 zone, the short-term bias stays bearish and a clean break under $3,150 could expose $3,050, $3,000 and even the $2,880–$2,850 support area.
Author  Mitrade
Nov 14, Fri
Ethereum (ETH) drops more than 5% after a failed push above $3,550, with price sliding to $3,153 and now holding below $3,350, the 100-hour SMA and a bearish trend line at $3,500; unless bulls reclaim the $3,350–$3,500 zone, the short-term bias stays bearish and a clean break under $3,150 could expose $3,050, $3,000 and even the $2,880–$2,850 support area.
placeholder
Top 3 Price Prediction: Bitcoin, Ethereum, Ripple – BTC, ETH, and XRP flash deeper downside risks as market selloff intensifiesBitcoin (BTC), Ethereum (ETH) and Ripple (XRP) trade in red on Friday after correcting more than 5%, 10% and 2%, respectively, so far this week.
Author  FXStreet
Nov 14, Fri
Bitcoin (BTC), Ethereum (ETH) and Ripple (XRP) trade in red on Friday after correcting more than 5%, 10% and 2%, respectively, so far this week.
placeholder
Gold Price Forecast: XAU/USD recovers above $4,100, hawkish Fed might cap gainsGold price (XAU/USD) recovers some lost ground to near $4,105, snapping the two-day losing streak during the early European session on Friday. The precious metal edges higher on the softer US Dollar (USD).  Traders will take more cues from the Fedspeak later on Monday.
Author  FXStreet
10 hours ago
Gold price (XAU/USD) recovers some lost ground to near $4,105, snapping the two-day losing streak during the early European session on Friday. The precious metal edges higher on the softer US Dollar (USD).  Traders will take more cues from the Fedspeak later on Monday.
placeholder
Bitcoin slides deeper into red as bears lean on $96,600 wall and eye $90,000Bitcoin extends its decline after failing to reclaim $96,500, trading below $95,000, the 100-hour SMA and a bearish trend line near $96,600; unless bulls can force a decisive close back above $96,600–$97,200, the short-term path of least resistance stays lower, with $92,500, $90,000 and the main $88,500 support zone in focus.
Author  Mitrade
8 hours ago
Bitcoin extends its decline after failing to reclaim $96,500, trading below $95,000, the 100-hour SMA and a bearish trend line near $96,600; unless bulls can force a decisive close back above $96,600–$97,200, the short-term path of least resistance stays lower, with $92,500, $90,000 and the main $88,500 support zone in focus.
placeholder
Bitcoin briefly loses 2025 gains as crypto plunges over the weekend.Bitcoin experienced a sharp decline this weekend, briefly erasing its 2025 gains and dipping below its year-opening value of $93,507. The cryptocurrency fell to a low of $93,029 on Sunday, representing a 25% drop from its all-time high in October. Although it has rebounded slightly to around $94,209, the pressures on the market remain significant. The downturn occurred despite the reopening of the U.S. government on Thursday, which many had hoped would provide essential support for crypto markets. This year initially appeared promising for cryptocurrencies, particularly after the inauguration of President Donald Trump, who has established the most pro-crypto administration thus far. However, ongoing political tensions—including Trump's tariff strategies and the recent government shutdown, lasting a historic 43 days—have contributed to several rapid price pullbacks for Bitcoin throughout the year. Market dynamics are also being influenced by Bitcoin whales—investors holding large amounts of Bitcoin—who have been offloading portions of their assets, consequently stalling price rallies even as positive regulatory developments emerge. Despite these sell-offs, analysts from Glassnode argue that this behavior aligns with typical patterns seen among long-term investors during the concluding stages of bull markets, suggesting it is not indicative of a mass exodus. Notably, Bitcoin is not alone in its struggles, as Ethereum and Solana have also recorded declines of 7.95% and 28.3%, respectively, since the start of the year, while numerous altcoins have faced even steeper losses. Looking ahead, questions linger regarding the viability of the four-year cycle thesis, particularly given the increasing institutional support and regulatory frameworks now in place in the crypto landscape. Matt Hougan, chief investment officer at Bitwise, remains optimistic, suggesting a potential Bitcoin resurgence in 2026 driven by the “debasement trade” thesis and a broader trend toward increased adoption of stablecoins, tokenization, and decentralized finance. Hougan emphasized the soundness of the underlying fundamentals, pointing to a positive outlook for the sector in the longer term.
Author  Mitrade
8 hours ago
Bitcoin experienced a sharp decline this weekend, briefly erasing its 2025 gains and dipping below its year-opening value of $93,507. The cryptocurrency fell to a low of $93,029 on Sunday, representing a 25% drop from its all-time high in October. Although it has rebounded slightly to around $94,209, the pressures on the market remain significant. The downturn occurred despite the reopening of the U.S. government on Thursday, which many had hoped would provide essential support for crypto markets. This year initially appeared promising for cryptocurrencies, particularly after the inauguration of President Donald Trump, who has established the most pro-crypto administration thus far. However, ongoing political tensions—including Trump's tariff strategies and the recent government shutdown, lasting a historic 43 days—have contributed to several rapid price pullbacks for Bitcoin throughout the year. Market dynamics are also being influenced by Bitcoin whales—investors holding large amounts of Bitcoin—who have been offloading portions of their assets, consequently stalling price rallies even as positive regulatory developments emerge. Despite these sell-offs, analysts from Glassnode argue that this behavior aligns with typical patterns seen among long-term investors during the concluding stages of bull markets, suggesting it is not indicative of a mass exodus. Notably, Bitcoin is not alone in its struggles, as Ethereum and Solana have also recorded declines of 7.95% and 28.3%, respectively, since the start of the year, while numerous altcoins have faced even steeper losses. Looking ahead, questions linger regarding the viability of the four-year cycle thesis, particularly given the increasing institutional support and regulatory frameworks now in place in the crypto landscape. Matt Hougan, chief investment officer at Bitwise, remains optimistic, suggesting a potential Bitcoin resurgence in 2026 driven by the “debasement trade” thesis and a broader trend toward increased adoption of stablecoins, tokenization, and decentralized finance. Hougan emphasized the soundness of the underlying fundamentals, pointing to a positive outlook for the sector in the longer term.
goTop
quote