Here's Billionaire Stanley Druckenmiller's Top Holding (Hint: It's Not Alphabet or Nvidia)

Source Motley_fool

Key Points

  • Most investors’ portfolios hold at least a couple of the market’s biggest companies, just because these names are best-known to most investors.

  • These crowded trades in already-massive companies, however, can mean their potential upside is limited.

  • Druckenmiller appears to remember that the market’s biggest winners are often the fast-growing up-and-comers before they become well-known names.

  • 10 stocks we like better than Natera ›

Your personal portfolio doesn't necessarily need to mirror a billionaire investor's holdings. But let's face it -- they manage billion-dollar portfolios for a reason.

And that's what makes Stanley Druckenmiller's current positions so interesting to investors on the hunt for a new pick. The former hedge fund manager doesn't own the obvious and usual suspects, such as Nvidia or Alphabet, even though these names are currently the world's biggest and most ownable publicly traded companies. Rather, Druckenmiller's family's top holding right now is its $600 million position -- 18% of the portfolio -- in a healthcare company called Natera (NASDAQ: NTRA).

Will AI create the world's first trillionaire? Our team just released a report on the one little-known company, called an "Indispensable Monopoly" providing the critical technology Nvidia and Intel both need. Continue »

Here's a closer look.

A biopharma lab technician is preparing a test sample.

Image source: Getty Images.

What's Natera?

With a market cap of just over $30 billion, Natera is not exactly a household name. But Druckenmiller seems to think it could eventually become one. And for good reason.

Natera offers a wide range of genetic testing, including prenatal testing for potential birthing-related problems to determining how a tumor is likely to respond to a particular cancer treatment to figuring out the likelihood that a patient's body will reject a transplanted organ. This information would have been difficult, if not impossible, to know before medical science was able to study DNA in detail.

Natera has taken this young science and made great strides in putting it to marketable use. Last year's top line of $2.3 billion was up 35% year over year. Analysts are looking for revenue of $2.8 billion this year, en route to $3.3 billion next year.

This is still just the beginning, though. An outlook from industry research outfit Precedence Research suggests the worldwide genetic testing business is set to grow at an average annual pace of more than 11% through 2035, when it could be worth more than $70 billion per year. Natera is well-positioned to capture more than its fair share of this growth.

The kicker: While not yet profitable, the company's moving in this direction. The analyst community expects this year's per-share loss of $1.58 to shrink to $0.32 per share next year, before swinging to a profit of $1.43 per share in fiscal 2028.

Given all of this, it's not difficult to see why Druckenmiller is willing to take such a sizable swing on this stock.

Just understand the risk

Granted, Druckenmiller can afford to take such a risk, just as he can afford to be patient if the stock underperforms for a while -- a luxury that most ordinary investors simply don't have. That's why you might want to think carefully before following his lead into this name.

You should also know that analysts' earnings forecasts are all over the proverbial map. While the consensus calls for a swing to a per-share profit of $1.43 in 2028, the underlying numbers range from a loss of $1.32 to a profit of $5.03.(Read between the lines: Nobody really knows exactly how well this company is going to grow its top and bottom lines between now and then.)

Still, Druckenmiller has found a name that, at the very least, is worth considering for a small place in your portfolio.

Should you buy stock in Natera right now?

Before you buy stock in Natera, consider this:

The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Natera wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years.

Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you’d have $449,393!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you’d have $1,366,006!*

Now, it’s worth noting Stock Advisor’s total average return is 983% — a market-crushing outperformance compared to 212% for the S&P 500. Don't miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors.

See the 10 stocks »

*Stock Advisor returns as of June 3, 2026.

James Brumley has positions in Alphabet. The Motley Fool has positions in and recommends Alphabet, Natera, and Nvidia. The Motley Fool has a disclosure policy.

Disclaimer: For information purposes only. Past performance is not indicative of future results.
placeholder
Bitcoin Price In Freefall As Panic Sweeps Through The MarketBitcoin price started a fresh decline below the $70,000 zone. BTC is consolidating and might continue to move down if it dips below $66,000. Bitcoin failed to stay above $70,500 and extended losses.
Author  NewsBTC
18 hours ago
Bitcoin price started a fresh decline below the $70,000 zone. BTC is consolidating and might continue to move down if it dips below $66,000. Bitcoin failed to stay above $70,500 and extended losses.
placeholder
Gold replaces US Treasuries as top global reserve asset, latest ECB report saysA recent report published by the European Central Bank today has stated that central banks globally now hold more gold than US government bonds and treasuries in their reserves for the very first time. Geopolitical tensions, concerns over a risk of sanctions, and a growing desire among some countries to lessen their exposure to dollar-denominated...
Author  Cryptopolitan
18 hours ago
A recent report published by the European Central Bank today has stated that central banks globally now hold more gold than US government bonds and treasuries in their reserves for the very first time. Geopolitical tensions, concerns over a risk of sanctions, and a growing desire among some countries to lessen their exposure to dollar-denominated...
placeholder
Crypto Crash Wipes Out 7% in 24 Hours: What’s Next?The total crypto market capitalization has fallen sharply to $2.32 trillion. The decline has wiped out roughly 17% of the market value in less than three weeks.Bitcoin (BTC) trades near $67,400, down
Author  Beincrypto
19 hours ago
The total crypto market capitalization has fallen sharply to $2.32 trillion. The decline has wiped out roughly 17% of the market value in less than three weeks.Bitcoin (BTC) trades near $67,400, down
placeholder
Google Shares Sink as AI Boom Forces Alphabet to Go Back on Strategy Critical to its StockGoogle stock fell after parent Alphabet (GOOGL) announced an $80 billion equity raise to fund artificial intelligence (AI) infrastructure. The move reverses years of buybacks that steadily shrunk its
Author  Beincrypto
19 hours ago
Google stock fell after parent Alphabet (GOOGL) announced an $80 billion equity raise to fund artificial intelligence (AI) infrastructure. The move reverses years of buybacks that steadily shrunk its
placeholder
Experts Warn Bitcoin Has a MicroStrategy Problem as BTC and MSTR Stock SinkBitcoin (BTC) and MicroStrategy (MSTR) stock plunged on Tuesday after the company disclosed its first BTC sale in 41 months. The move reignited debate over how much the asset depends on one corporate
Author  Beincrypto
19 hours ago
Bitcoin (BTC) and MicroStrategy (MSTR) stock plunged on Tuesday after the company disclosed its first BTC sale in 41 months. The move reignited debate over how much the asset depends on one corporate
goTop
quote