Revenue was flat at $16.6 billion, with COVID and Prevnar sales falling while Eliquis, Padcev, Vyndaqel, Nurtec, and Lorbrena grew.
Pfizer raised its full-year revenue and adjusted EPS guidance.
Adjusted diluted EPS held at $0.87, but the underlying earnings mix shifted, and reported diluted EPS fell to $0.56 from $0.62.
Pfizer (NYSE: PFE) reported flat third-quarter revenue of $16.6 billion and raised its full-year outlook. Shares slipped about 0.2% in premarket trading. Eliquis and other newer drugs offset the drop in COVID and Prevnar sales, but the growth leaned on price, and adjusted earnings held only because offsetting items balanced out.
Revenue: $16.6 billion, relatively flat versus a year ago.
Missed AI’s "Act 1"? Act 2 Could Be 15x Bigger. Most investors think they missed the AI boat because they didn't buy Nvidia in 2005. But according to our analysts, we’re only at the end of "Act 1"—the R&D phase. "Act 2" is the global rollout. Continue »
Revenue excluding Comirnaty and Paxlovid: up 7% operationally.
Reported diluted EPS: $0.56, versus $0.62.
Adjusted diluted EPS: $0.87, versus $0.87.
Full-year revenue guidance: raised to $62.0 billion to $64.0 billion, from $60.5 billion to $62.5 billion.
Full-year adjusted diluted EPS guidance: raised to $2.95 to $3.05, from $2.80 to $3.00.
Paxlovid and Comirnaty sales fell on fewer infections and narrower vaccine recommendations, and the Prevnar family also declined. Eliquis, Padcev, Vyndaqel, Nurtec, and Lorbrena grew enough to offset that drop, according to the release. Excluding Comirnaty and Paxlovid, revenue grew 7% operationally.
Image source: Getty Images.
Eliquis deserves a closer look. It brought in $2.52 billion, up 25% year over year, beating the roughly $2.40 billion analysts expected. The release credits higher U.S. net price, driven by lower rebates and better channel mix, as a key driver. A price gain can be harder to repeat than a demand gain, especially with the Medicare negotiated price now in effect for 2026.
Adjusted earnings held because offsetting items balanced out. Reported diluted EPS fell to $0.56 from $0.62, while adjusted diluted EPS stayed at $0.87. The company's guidance raise reflects both the quarter and the higher cost-cutting target, roughly $9.7 billion in net savings through 2029.
Watch whether Eliquis's U.S. growth holds, since the Medicare negotiated price is in effect this year and the release says Pfizer expects no material incremental impact from the Part D redesign. Also track research spending and the progress on the late-stage pipeline, which Pfizer says includes eight key pivotal study starts, one pivotal readout, and two regulatory decisions this quarter.
Before you buy stock in Pfizer, consider this:
The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Pfizer wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years.
Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you’d have $336,195!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you’d have $1,241,567!*
Now, it’s worth noting Stock Advisor’s total average return is 875% — a market-crushing outperformance compared to 208% for the S&P 500. Don't miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors.
See the 10 stocks »
*Stock Advisor returns as of November 3, 2026.
Savannah Maxwell has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Pfizer. The Motley Fool has a disclosure policy.