Kymera Stock Up 130% as $135 Million Buy Boosts Immunology Bet
Key Points
Baker Bros. Advisors added 2,005,813 shares of Kymera Therapeutics; the estimated transaction value was $135.45 million.
Meanwhile, the quarter-end position value increased by $297.15 million, reflecting both new purchases and share price moves.
The post-trade stake stood at 8,657,242 shares valued at $673.62 million.
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Baker Bros. Advisors reported a buy of 2,005,813 Kymera Therapeutics (NASDAQ:KYMR) shares in its February 17, 2026, SEC filing, an estimated $135.45 million trade based on quarterly average pricing.
What happened
According to a February 17, 2026 SEC filing, Baker Bros. increased its holding in Kymera Therapeutics (NASDAQ:KYMR) by 2,005,813 shares. The estimated trade value was $135.45 million, based on the average closing price during the fourth quarter of 2025. The fund’s quarter-end position value in Kymera Therapeutics rose by $297.15 million, a change that includes both trading activity and share price appreciation.
What else to know
- Top holdings after the filing:
- INCY: $3.04 billion (17.8% of AUM)
- ONC: $2.67 billion (15.7% of AUM)
- MDGL: $1.25 billion (7.3% of AUM)
- INSM: $1.15 billion (6.7% of AUM)
- ACAD: $1.15 billion (6.7% of AUM)
- As of February 17, 2026, KYMR shares were priced at $84.84, up 130% over the past year and well outperforming the S&P 500 by 118.13 percentage points.
Company overview
| Metric | Value |
|---|---|
| Price (as of market close 2026-02-17) | $84.84 |
| Market Capitalization | $6.70 billion |
| Revenue (TTM) | $43.73 million |
| Net Income (TTM) | ($295.12 million) |
Company snapshot
- Kymera Therapeutics develops small-molecule therapeutics targeting disease-causing proteins, with lead programs addressing immunology-inflammation diseases, hematologic malignancies, and solid tumors.
- The firm operates a research-driven business model leveraging proprietary protein degradation technology.
- It targets biopharmaceutical companies, healthcare providers, and patients affected by autoimmune disorders and cancer.
Kymera Therapeutics, Inc. is a clinical-stage biotechnology company focused on leveraging targeted protein degradation to address serious diseases with high unmet need. The company’s pipeline includes programs in immunology, oncology, and fibrosis, supported by a growing portfolio of proprietary technologies. Strategic emphasis on first-in-class therapies and partnerships with leading industry players position Kymera as an innovator in the protein degradation space.
What this transaction means for investors
It’s not surprising that a fund might lean into this stock. Kymera enters 2026 with what management calls an industry-leading oral immunology pipeline and roughly $1.6 billion in cash, pushing runway into 2029. Meanwhile, KT-621 is already in Phase 2b for atopic dermatitis and asthma, with Fast Track designation from the FDA and early data showing deep STAT6 degradation and biomarker improvements. And KT-579, targeting IRF5, is expected to enter Phase 1 this quarter, with data in the second half of the year. In other words, this is not a single-asset story.
Shares at $84.84 are up 130% over the past year, well ahead of the broader market, and within a portfolio already concentrated in oncology and metabolic biotech leaders measured in the billions, this position sits as a meaningful but not dominant allocation.
Ultimately, long-term investors should watch whether Phase 2b readouts confirm biologics-like efficacy with oral convenience. If the degrader platform delivers consistent clinical validation across indications, the multiple could expand further. If efficacy narrows versus incumbents, enthusiasm may cool quickly.
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Jonathan Ponciano has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends BeOne Medicines Ag and Incyte. The Motley Fool recommends Kymera Therapeutics. The Motley Fool has a disclosure policy.
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