Anika (ANIK) Q3 2025 Earnings Call Transcript

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DATE

Wednesday, Nov. 5, 2025 at 8:30 a.m. ET

CALL PARTICIPANTS

President and Chief Executive Officer — Dr. Cheryl Renee Blanchard

Executive Vice President, Chief Financial Officer, and Chief Operating Officer — Stephen D. Griffin

Manager, Investor Relations — Matt Hall

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TAKEAWAYS

Total Revenue -- $27.8 million, representing a 6% decrease, primarily due to lower pricing in the U.S. OA pain management OEM channel.

Commercial Channel Revenue -- $12 million, up 22%, driven by demand in regenerative solutions and international OA pain management.

Regenerative Solutions Growth -- 25% year-over-year, with U.S. Integrity procedures up for the sixth consecutive quarter to about 500, reaching nearly 300 surgeon users.

International OA Pain Management Revenue -- Increased 21% during the quarter, with year-to-date growth at 6% due to shipment timing in Q2.

OEM Channel Revenue -- $15.8 million, down 20%, reflecting reduced pricing on MONOVISC and OrthoVISC, with MONOVISC unit volume up 11% but average price down 17% year-to-date.

Gross Margin -- 56%, down 10 percentage points year over year, but up 5 percentage points from the prior quarter, recovering from earlier production disruptions.

Operating Expenses -- $18.8 million, a 3% decline; selling, general, and administrative expenses fell 12%, and general and administrative expenses fell 17%, offset by a 17% increase in research and development driven by CINGAL studies.

Adjusted EBITDA -- $900,000, down $3.7 million year-over-year, but up $1 million sequentially; improvement attributed to expense reductions partially offsetting lost high-margin sales.

Operating Cash Flow -- $6.9 million, up from $5 million, driven by strengthened working capital management and cost discipline.

Cash Position and Capital Allocation -- $58 million in cash and no debt at quarter end; commencing a second $15 million share repurchase under Rule 10b5-1 through June 2026.

CINGAL and HYALOFAST Milestones -- Completed first CINGAL toxicity study and began screening for the CINGAL bioequivalence study; submitted third and final HYALOFAST PMA module to the FDA on October 31.

HYALOFAST Clinical Data -- U.S. Phase III study failed co-primary endpoints but showed clinically meaningful improvements in secondary endpoints and significance in supplemental responder and observed data analyses.

2025 Guidance Maintained -- Commercial channel revenue expected at $47–$49.5 million (12%-18% growth), OEM channel at $62–$65 million (16%-20% decline), and adjusted EBITDA guidance range of positive 3% to negative 3%.

Strategic Review Conclusion -- Formal process ended; focus remains on core product growth and operational efficiency, with internal investments ranked above share repurchases and M&A.

SUMMARY

Management confirmed resilient commercial channel expansion and reiterated the expected double-digit growth in regenerative solutions, offset by pricing headwinds impacting the OA pain management OEM channel. Cash generation improved, with higher operating cash flow results and no debt obligations, supporting both share repurchases and reinvestment in core product launches. The clinical submission milestone for HYALOFAST and progression of CINGAL U.S. regulatory efforts were highlighted as pivotal near-term value drivers for the company’s innovation pipeline.

J&J MedTech exercised its option to extend the MONOVISC license and supply agreement through December 2031.

International CINGAL sales surpassed one million injections since 2016, demonstrating global demand traction outside the U.S.

Integrity product launches expanded into 10 countries, with introduction of new SKUs for broader tendon applications and ongoing limited release of additional shapes and sizes.

Dr. Cheryl Renee Blanchard stated, "over sixty percent of users have completed multiple cases," signaling repeat usage and deepening clinical adoption.

Stephen D. Griffin noted, "We are maintaining our full-year 2025 guidance," signaling stability in outlook despite continued OEM channel pressure.

INDUSTRY GLOSSARY

OEM Channel: Business segment where products are sold to other companies (often under long-term agreements) for marketing and distribution, typically at wholesale pricing.

PMA: Premarket Approval, the FDA's regulatory pathway for Class III medical devices, requiring substantial evidence for safety and effectiveness.

BMAC: Bone Marrow Aspirate Concentrate, often used in orthopedics and regenerative medicine to enhance tissue repair with autologous cells.

SKUs: Stock Keeping Units, unique product variations identified for inventory and sales management.

Adjusted EBITDA: Non-GAAP measure of earnings before interest, taxes, depreciation, and amortization, adjusted for certain non-recurring or non-cash items.

NDA: New Drug Application, the FDA application required to seek U.S. approval to market a new pharmaceutical product.

Full Conference Call Transcript

Dr. Cheryl Renee Blanchard, President and Chief Executive Officer, and Stephen D. Griffin, Executive Vice President, Chief Financial Officer, and Chief Operating Officer, who will present our third quarter 2025 financial results and business highlights. Please take a moment and open the slide presentation and refer to slide number two.

Matt Hall: Before we begin, please understand that certain statements made during the call today constitute forward-looking statements as defined in the Securities Exchange Act of 1934. These statements are based on our current beliefs and expectations and are subject to certain risks and uncertainties. The company's actual results could differ materially from any anticipated future results, performance, or achievements. We make no obligation to update these statements should future financial data or events occur that differ from the forward-looking statements presented today. Please also see our most recent SEC filings for more information about risk factors that could affect our performance.

In addition, during the call, we may refer to several adjusted or non-GAAP financial measures, which may include adjusted EBITDA, adjusted net income from continuing operations, and adjusted earnings per share from continuing operations, which are used in addition to results presented in accordance with GAAP financial measures. We believe that non-GAAP measures provide an additional way of viewing aspects of our operations and performance. But when considered with GAAP financial measures and the reconciliation of GAAP measures, they provide an even more complete understanding of our business. A reconciliation of these adjusted non-GAAP financial results to the most comparable GAAP measurements is available at the end of the presentation slide deck and our third quarter 2025 press release.

And now, I'd like to turn the call over to our President and CEO, Dr. Cheryl Renee Blanchard. Cheryl?

Cheryl Renee Blanchard: Thanks, Matt. Good morning, everyone, and thanks for joining us today to discuss Anika Therapeutics, Inc.'s third quarter 2025 results. Please turn to Slide three. This quarter reflects strong execution across our strategic priorities, including robust commercial channel revenue growth, completing the filing of the third and final PMA module for 6% compared to the same period last year, as expected as Johnson and Johnson continues efforts to stabilize pricing in our important and profitable U.S. OA pain management business, which accounts for the majority of our OEM channel revenue. As a note, J&J announced their intent to separate their orthopedic business to enhance strategic and operational focus.

We do not anticipate any negative impact to our OA pain management business related to that separation, and in fact, after the quarter, J&J MedTech exercised its option to extend the current license and supply agreement for MonoVisc for another five-year term through December 2031. The expected results from our OEM channel were offset by strong continued momentum in our commercial channel, where we delivered double-digit growth in the quarter, advancing our strategic priorities while moving HYALOFAST and CINGAL closer to FDA approval and launch. Commercial channel revenue grew 22%, fueled by strong integrity growth, continued growth of HYALOFAST outside the U.S., and international growth in OA pain management.

Additionally, the steps we've taken to improve our cost structure are flowing through, with SG&A expenses down 12% year over year and overall operating expenses down 3%, driving improved profitability and free cash flow. Turning to our commercial channel portfolio, integrity procedures in the U.S. grew for the sixth consecutive quarter, driving regenerative solutions growth of 25% year over year. Integrity growth is outpacing the overall U.S. soft tissue augmentation market, keeping us on track to more than double integrity procedures and revenue in 2025 compared to last year. As shown on slide four, about 500 Integrity procedures were performed during the quarter, bringing our number of surgeon users to nearly 300.

Our U.S. commercial team remains focused on expanding adoption and repeat use, supporting existing users as they integrate Integrity more fully into their practice, while also training new surgeons on its safe and effective use. Notably, over sixty percent of users have completed multiple cases, a strong indicator of growing and sustained clinical confidence. We are also excited that we've started limited launches of INTEGRETY outside the U.S., and cases have been performed in 10 countries. This growing base of experienced users demonstrates sustained clinical confidence and adoption of this game-changing technology that offers both enhanced regenerative capacity and greater strength when compared to competitive products.

During the quarter, we also initiated the limited release of the first SKU of the larger shapes and sizes of Integrity, designed for a variety of tendon applications, including in the hip, knee, and foot and ankle. A number of surgeries have been performed, and the initial feedback from surgeons has been positive. Additional SKUs of shapes and sizes that are designed for more specific tendon augmentation applications will be released in the coming quarters. We expect these additions to further accelerate adoption and support continued commercial momentum into 2026. Also contributing to our commercial channel growth was the continued success of our international team driving HYALOFAST expansion and delivering double-digit gains in international OA pain management revenue.

The team partnered closely with distributors to strengthen business in existing markets and expand into new geographies. International OA pain management revenue grew 21% year over year, primarily driven by the timing of distributor orders. Year to date, that business is up 6% compared to 2024. This successful quarter for our international business was underscored by a major milestone. We have now surpassed sales of 1,000,000 CINGAL injections since the 2016 launch. The strong uptake of CINGAL outside the U.S. is a testament to its effectiveness to relieve both short and long-term pain and get patients back to active living.

Turning to HYALOFAST, on October 31, we submitted the third and final module of our PMA to the FDA, marking a major milestone in our U.S. regulatory pathway for our breakthrough cartilage repair device. We look forward to engaging with the agency to progress toward U.S. approval and commercialization. Concurrent with earnings, we have also released the data from our U.S. Phase III fast track study. As previously reported, while HYALOFAST consistently demonstrated improvements in pain and function, the study did not meet its two co-primary endpoints under the original statistical framework. This was in part due to a disproportionate amount of missing data in the microfracture active control arm.

While HYALOFAST showed clinically meaningful improvements in both Coo's pain and iKDC function from baseline at twenty-four months, it was not statistically significant when compared to the active microfracture control arm. Statistically significant improvements were achieved in relevant key secondary endpoints, including COOS Sports and Recreation Function, quality of life, and total COOS, all of which have been used as the basis for FDA approvals of other cartilage repair products. In addition, because the data was not normal and not missing at random, as assumed in the predefined statistical analysis plan, supplemental statistical analyses were prepared for FDA consideration. These analyses include a review of observed data, which is the data without statistical imputations.

In the observed data analysis, we achieved significance for Coos pain. The post hoc analysis also included responder analyses for several outcome measures. A responder analysis provides the number of patients in the study who achieved a clinically meaningful level of improvement. In the Fast Track study, more HYALOFAST patients achieved higher levels of improvement in pain at twenty-four months than microfracture patients did, and with statistical significance. We believe these additional analyses confirm the consistent and meaningful clinical benefit that HYALOFAST with BMAC brings to patients with cartilage defects.

We're encouraged by the strength and consistency of the data we have submitted to the FDA, both from the Fast Track study and the over fifteen years of independent clinical experience outside the U.S. The international experience continues to demonstrate HYALOFAST safety and efficacy across a broad range of patients, with over thirty-five thousand treated to date as we continue to see strong penetration of HYALOFAST in the over 35 markets where it is sold today. Now turning to CINGAL, our next-generation OA pain management product. During the quarter, we made meaningful progress toward our U.S. NDA submission.

We successfully completed the first of two toxicity studies and initiated patient screening for the bioequivalence study, which remains on track to begin before the end of the year. As a reminder, these studies represent the final steps required for our NDA filing. We're encouraged by our continued progress with this important program and remain focused on advancing CINGAL toward regulatory submission and ultimately commercial availability in the U.S. market. Lastly, beginning in 2023, the company undertook a comprehensive strategic review evaluating a broad range of alternatives. We have formally concluded that process and remain focused on executing our product growth strategy and enhancing operational performance to create shareholder value and capital.

As part of that commitment, we are commencing a second $15,000,000 share repurchase under our previously announced program. We continue to prioritize key growth and regulatory milestones, including growing integrity, engaging with the FDA on the HYALOFAST PMA submission, completing the CINGAL bioequivalence study and subsequent NDA submission, and delivering ongoing operational improvements aimed at strengthening profitability and cash flow. And with that, I'll now turn the call over to Steve for a detailed review of our financial results.

Stephen D. Griffin: Thank you, Cheryl, and thank you all for joining us. Our third quarter results reflect steady progress across key areas in both profit and cash flow, with performance in line with expectations and signs of continued momentum. We're executing on our key objectives, and the resulting improved financial performance is showing. Please refer to slide five of the presentation as I provide financial updates on the quarter. In the third quarter, Anika Therapeutics, Inc. generated $27.8 million in total revenue, a 6% decline compared to the same period in 2024. Our commercial channel, which includes globally distributed, highly differentiated products, delivered $12 million, up 22% year over year.

This growth was driven by continued momentum in our regenerative solutions, which was up 25% in the quarter, as the Integrity Implant System continues to gain market share. Integrity has now delivered sequential growth for six consecutive quarters in the United States and remains on track to more than double in 2025. With the launch of larger shapes and sizes in the third quarter, we're encouraged by the continued expansion and trajectory of the platform. Also within our commercial channel, international OA pain sales grew 21% in the quarter, as our international sales team continues to gain share with our existing product portfolio. Year-to-date growth stands at 6%, slightly below expectations due to shipment timing impacted by second-quarter production-related disruptions.

We expect any remaining impacts to be resolved before year-end. While this channel can be somewhat variable quarter to quarter, it continues to show strong underlying momentum, building on several years of consistent double-digit growth. Revenue in the OEM channel, which includes our domestic OA pain and non-orthopedic products sold by third parties under long-term agreements, declined 20% in the third quarter to $15.8 million, in line with our full-year guidance, primarily due to pricing pressure on end-user sales. OrthoVisc sales were lower, reflecting both reduced pricing and a continued shift towards single-injection treatments. MONOVISC saw strong unit growth, up low double digits in the quarter, though this was offset by a double-digit decline in pricing.

Year-to-date, MONOVISC unit volume is up 11%, while the average price is down 17%. Despite ongoing pricing pressure, we continue to expect more stable revenue trends as we head into 2026, supported by anticipated unit volume growth that we believe will mostly offset price dynamics, resulting in flat to modestly lower revenue in line with our previously provided financial framework. Recall, J&J is responsible for marketing and selling OA Paint products in the U.S. We continue to work with them in an effort to drive for greater price stability and market expansion. On a combined basis, MONOVISC and OrthoVISC continue to lead the U.S. market and remain profitable contributors to our business.

The remainder of our OEM business, our non-orthopedic sales, declined in the quarter due to the timing of customer orders. Third-quarter gross margin was 56%, a decrease of 10 percentage points year over year but an improvement of five percentage points sequentially from the second quarter. The year-over-year decline was primarily driven by a $3.2 million in MONOVISC and OrthoVISC sales to J&J, largely due to lower pricing. This impacted both transfer units and royalty revenues and directly reduces gross profit. Sequential margin improvement reflects our recovery from early summer production disruptions, which had previously led to elevated inventory reserves and negatively impacted gross profit.

Turning to operating expenses, total third-quarter OpEx was $18.8 million, a decrease of $700,000 or 3% compared to the same period last year. Selling, general, and administrative expenses declined $1.7 million or 12%, primarily driven by headcount-related cost savings and lower stock-based compensation. Following the two divestitures completed earlier in 2025, we streamlined and optimized our organizational structure to better align with our strategic priorities and reduce operating costs. Notably, general and administrative expenses were down 17% year over year. We remain focused on identifying cost savings initiatives while continuing to invest in areas that support sustainable, long-term growth.

Partially offsetting the G&A savings, research and development expenses increased $1 million or 17%, driven by the costs associated with the CINGAL toxicity study. Year-to-date, R&D expenses are up 1%, driven by a $1.8 million increase in external expenses, largely due to a $2 million increase in CINGAL pre-filing requirements. In contrast, total internal R&D expenses are down 12% year to date versus 2024, underscoring our commitment to operational efficiency while maintaining momentum in key development areas. Adjusted EBITDA from continuing operations was positive in the quarter, totaling $900,000, a decline of $3.7 million compared to the same period in 2024. This result exceeded the anticipated breakeven level and represented a $1 million improvement over the second quarter.

The year-over-year decline was primarily driven by reduced high-margin revenue from J&J, partially offset by meaningful reductions in operating expenses. The improved expense profile contributed to profitability that was better than previously guided. Now turning to cash and liquidity, Anika Therapeutics, Inc. delivered strong operating cash flow of $6.9 million in the third quarter, up from $5 million in the same period last year. This improvement was driven by favorable timing, stronger working capital management, and disciplined cost controls. Year-to-date operating cash flow totaled $6.6 million, a $2.8 million increase over 2024. This performance reflects the company's disciplined approach to working capital and expense management.

We invested $1.9 million in capital expenditures during the quarter, an increase of $700,000 year over year, primarily due to timing. These investments are focused on expanding capacity at our Massachusetts manufacturing facility to support anticipated volume growth across MonoVisc, CINGAL, Integrity, and HYALOFAST. This positions us to efficiently scale operations and meet future demand. We ended the third quarter with $58 million in cash and no debt. As Cheryl mentioned, we are commencing a second $15 million share repurchase, consistent with the plan announced in May 2024. This repurchase will be executed under a 10b5-one program, which we expect to complete by June 2026.

It reflects our ongoing commitment to returning capital to shareholders while preserving the flexibility to pursue strategic growth initiatives. Now on Slide six, I'll review our full-year financial outlook for 2025. We are maintaining our full-year 2025 guidance. We continue to expect our commercial channel to generate between $47 and $49.5 million in revenue, representing a year-over-year growth of 12% to 18%. Our OEM channel remains on track to deliver between $62 and $65 million in revenue for 2025, representing a year-over-year decline of 16% to 20%. At the midpoint of an 18% decline, this range reflects higher volumes offset by lower pricing from J&J.

Now turning to profitability, we are maintaining our 2025 adjusted EBITDA guidance range of positive 3% to negative 3%. Our liquidity remains strong, with no need to raise capital, and we remain confident in our ability to execute on our strategy. We continue to be focused on improving our expense profile to deliver positive operating cash flow. This financial discipline enables us to reinvest in the business, capitalize on the value propositions of our product pipeline, and ultimately deliver sustainable returns for our shareholders. With that, I will now turn the call back over to Cheryl.

Cheryl Renee Blanchard: Thanks, Steve. In closing, we're pleased with Anika Therapeutics, Inc.'s solid third-quarter performance, which reflects continued momentum in our commercial channel, disciplined expense management, and meaningful progress across our pipeline. Additionally, with strong operating cash flow, a healthy balance sheet, and a clear path toward key regulatory milestones, in total, we believe this will deliver long-term value for shareholders. We want to thank our shareholders for their continued support, and we'd also like to extend our deepest gratitude to the entire Anika team, whose dedication to developing, manufacturing, and delivering world-class products enables us to restore active living for patients around the world. And with that, we'll open up the line for questions. Operator? Please proceed.

Operator: Thank you. Ladies and gentlemen, we will now begin the question and answer session. Should you wish to cancel your request, please press the star followed by the two. If you are using a speakerphone, please lift the handset before pressing any, please. Once again, it's star one should you wish to ask a question. Your first question is from Michael John Petusky from Barrington Research. Your line is now open.

Michael John Petusky: Hey, good morning. Thanks for some of the additional detail in the presentation today. That's great. So I guess I want to ask a question around integrity. Cheryl, in terms of what you would view as the bigger priority or maybe the lower hanging fruit, I mean, is it driving increased utilization with your existing surgeon base? Is it doing more trainings and expanding the footprint? I mean, can you just sort of talk about how you guys are approaching maybe turning 300 surgeons into six hundred and five hundred cases a quarter into a thousand cases a quarter? Like, how do you get there? Thanks.

Cheryl Renee Blanchard: Great question. Thanks for that, Mike. So I'd say, first of all, that we're feeling very bullish in the U.S. market with our team coming from a position of strength because what we're seeing from the surgeon reaction and adoption, new surgeon use, and further penetration with existing surgeons is that this product really does provide significant clinical advantages. It's stronger, has higher suture retention even when wet, and it has additional regenerative capacity. It just does things that the existing products out there don't do.

So I would tell you, though, that we are probably equal parts focused on going out and getting new surgeons, getting new excited about the technology, and also continuing to do training and education on the safe and effective use of the product for new and existing surgeons, especially as we continue to launch these additional SKUs that are really designed for use in the other tendon applications in the hip, in the knee, in the foot and ankle. So I would say it's really across the board, and our team is very busy doing both. Obviously, we've talked about this year that we are on track to double this year. And so we continue to invest in this product.

We think it's a great product. We believe in what it's doing, and we're excited that team to continue to drive both penetration and acquiring new customers.

Michael John Petusky: Okay. Alright. Great. And, I guess, if you could just remind me and maybe others, the timing for sort of wrapping up everything related to CINGAL bioequivalence and the second toxicity. Is that sort of mid-twenty-six? Is that when you hope to sort of wrap all of that up, or am I misremembering?

Cheryl Renee Blanchard: No. I don't think you're we have not given a specific updated timeline, which we will be in a position to do at the next earnings call because we need to get the bioequivalence study started. We've talked about we are on track to start that by the end of the year. We started screening patients for that study. And as soon as that study gets started, we'll be able to provide a more fulsome update on the timeline. We have one last toxicity study that will be done in the first quarter, and then the timing of the bioequivalence study is really what's going to dictate our fulsome timeline to get to an NDA filing.

But everything is on track as we sit here today.

Michael John Petusky: Okay. And then just one more. This is probably for Steve. Steve, in terms of capital deployment priorities, obviously, you guys called out the share repurchase. Can you just talk about either ranking or how you guys think about sort of share repurchase relative to internal investment relative to M&A? Obviously, you have a balance sheet that could support some multiple things. Can you just talk about how you think about capital deployment? Thanks.

Stephen D. Griffin: Absolutely. I appreciate the question, Mike. When we look at the hierarchy of our capital needs, I'd say first and foremost, we have internal investment that we're making into our business today. We've shared that we're investing, you know, approximately $14 million of profit into our regenerative solutions portfolio, which is, you know, the launch of Integrity and then the preparations associated with HYALOFAST. We look at that as a strategic investment that we're making as part of the growth of our product pipeline. That's first and foremost that we talk about. Second is the need for CapEx in the business to support those product launches.

Most of all of our CapEx is associated with our Bedford-based manufacturing facility to support the growth of our cross-selling products in CINGAL and MONOVISC as well as all of our high products, Integrity and HYALOFAST. And then third on that list would be the share repurchase that we've communicated today. You know, are there other actions that we could do and things we could look at? Certainly. We have a long list of things that we consider outside of the ones that I've just referenced, M&A being one of them.

But at this point, that's not something that the company is ready to undertake, and I'd say those first three are the areas that we pay the most attention to in terms of ranking our priorities.

Michael John Petusky: Okay. And then I actually let me sneak one more in, and then I'll I promise I'll get off and let other people ask questions. Steve, in terms of the production issues, I was under the impression that had largely been resolved earlier in Q3. It seems like some of that persisted. Is that a different issue? Or is that a hangover from the same issue?

Stephen D. Griffin: It's the latter. It's the hangover from the same issue. So from a resolution, you know, we're back to where we are from a yield perspective where we historically were. It's just about getting back on all of our POs for customers that we were not on track to. So this is just a matter of available capacity and running our teams over weekend shifts and the like to get back to PO, which is why I focus around getting it back to healthy by year-end. You know, it's a it is obvious we take every customer PO very seriously.

But it has a small impact on some of our OUS customers and a very minimal impact on our US-based customer.

Michael John Petusky: Okay. I think you had said that you had expected overall gross margin to sort of return to, like, the high 50s, like 58%, 59% in the second half. Is that maybe tracking a quarter behind? Like essentially or should we expect gross margin in Q4 to look more like Q3 or more like high fifties?

Stephen D. Griffin: I guess it's probably between where we are today and a little bit higher towards the fourth quarter. A lot of it comes down to the recovery from a product shipping perspective, so I would say that's probably more associated with some of the current gross margin dynamics.

Michael John Petusky: Okay. But 58, 59 longer term is doable, I assume.

Stephen D. Griffin: Yeah. A lot of that comes down to pricing with J&J. Right? So as you know, that's a very profitable piece of our business. So I don't really give long-term gross margin projections just because that pricing has been so volatile. You know, what you're seeing us return to is, you know, north of 55, between fifty-five and sixty. That's kind of a more normalized level for the business today, barring changes that could occur from a pricing perspective.

Michael John Petusky: Okay. Thank you so much.

Operator: Thank you. There are no further questions at this time. And that concludes our question and answer session for today. Ladies and gentlemen, the conference call has now ended. Thank you all for joining. You may now disconnect your lines.

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