Why Madrigal Pharmaceuticals Stock Slumped on Tuesday

Source Motley_fool

Key Points

  • The bull case wasn't helped by an analyst's recommendation downgrade.

  • That pundit now feels the biotech's shares only rate a hold.

  • 10 stocks we like better than Madrigal Pharmaceuticals ›

The New Year's Champagne turned flat for Madrigal Pharmaceuticals (NASDAQ: MDGL) on Tuesday. Investors traded out of the commercial-stage biotech following an analyst's recommendation downgrade. This resulted in the stock's price eroding by more than 5% that trading session.

A high bar

The prognosticator behind the downgrade was Wolfe Research's Andy Chen. Well before market open, Chen changed his recommendation on Madrigal to peerperform (hold, in other words) from his previous outperform (buy), at a $572 per share price target.

Where to invest $1,000 right now? Our analyst team just revealed what they believe are the 10 best stocks to buy right now, when you join Stock Advisor. See the stocks »

Two people in white lab coats looking at a computer display.

Image source: Getty Images.

His main concern, according to reports, is that Madrigal stock is expensive relative to its performance following a significant bull run on its shares.

This was aided greatly by the Food and Drug Administration's (FDA) 2024 approval of the company's Rezdiffra, which, for a time, made the drug the only approved treatment for the liver disorder now known as metabolic dysfunction-associated steatohepatitis (MASH). Several encouraging quarterly earnings reports helped, too.

Chen expressed skepticism that Madrigal could earn the $6 billion in annual revenue some of the more optimistic market professionals anticipate. Even in the unlikely case that it did, he wrote, the stock would still not be a bargain at current levels.

Victim of success

While Rezdiffra is unarguably a huge success story for Madrigal, I'd agree with Chen that its quick rise is essentially priced into the company's stock these days. Given that, I'd probably look elsewhere for biotech and pharmaceutical stocks with more reasonable valuations.

Should you buy stock in Madrigal Pharmaceuticals right now?

Before you buy stock in Madrigal Pharmaceuticals, consider this:

The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Madrigal Pharmaceuticals wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years.

Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you’d have $493,290!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you’d have $1,153,214!*

Now, it’s worth noting Stock Advisor’s total average return is 973% — a market-crushing outperformance compared to 195% for the S&P 500. Don't miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors.

See the 10 stocks »

*Stock Advisor returns as of January 6, 2026.

Eric Volkman has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

Disclaimer: For information purposes only. Past performance is not indicative of future results.
placeholder
BOJ Set to Hike Rates Amid Inflation Pressures and Yen Weakness The Bank of Japan is expected to raise its benchmark interest rate to 0.75% on December 19, marking its first increase since early 2025, amidst ongoing inflation and a weakening yen. Analysts predict additional hikes in 2026 as the central bank navigates renewed monetary policy normalization under Governor Kazuo Ueda.
Author  Mitrade
Dec 18, 2025
The Bank of Japan is expected to raise its benchmark interest rate to 0.75% on December 19, marking its first increase since early 2025, amidst ongoing inflation and a weakening yen. Analysts predict additional hikes in 2026 as the central bank navigates renewed monetary policy normalization under Governor Kazuo Ueda.
placeholder
Oil Prices Surge Amid U.S. Crackdown on Venezuelan Tankers and Middle East Tensions Oil prices rose in early Asian trading as the U.S. targets Venezuelan oil tankers amid geopolitical worries over Iran. Supply disruption fears contribute to rising Brent and WTI crude prices.
Author  Mitrade
Dec 22, 2025
Oil prices rose in early Asian trading as the U.S. targets Venezuelan oil tankers amid geopolitical worries over Iran. Supply disruption fears contribute to rising Brent and WTI crude prices.
placeholder
Asian Markets Open 2026 with Record-Breaking Rally on Regional Strength, AI OptimismAsian equities have kicked off 2026 with their strongest start on record, outpacing the United States as investors shift capital toward the region’s tech sector, currencies, and corporate bonds amid attractive valuations and AI-driven growth prospects.
Author  Mitrade
Jan 06, Tue
Asian equities have kicked off 2026 with their strongest start on record, outpacing the United States as investors shift capital toward the region’s tech sector, currencies, and corporate bonds amid attractive valuations and AI-driven growth prospects.
placeholder
Newmont Goldcorp Faces Production Dip After Bushfire Disrupts Operations in Western Australia Newmont Goldcorp projects a 60,000-ounce decline in gold production for Q1 2026 due to a recent bushfire affecting its Boddington project in Western Australia. Operations have resumed at reduced capacity, with full restoration expected by February.
Author  Mitrade
23 hours ago
Newmont Goldcorp projects a 60,000-ounce decline in gold production for Q1 2026 due to a recent bushfire affecting its Boddington project in Western Australia. Operations have resumed at reduced capacity, with full restoration expected by February.
placeholder
Bitcoin Retreats to $92K After Sharp Sell-Off Triggers Over $440M in LiquidationsBitcoin’s strong start to 2026 was interrupted on Tuesday as a wave of selling erased much of its recent gains, triggering more than $440 million in leveraged position liquidations. Analysts view the pullback as a short-term hurdle in a broader recovery trend rather than a reversal.
Author  Mitrade
17 hours ago
Bitcoin’s strong start to 2026 was interrupted on Tuesday as a wave of selling erased much of its recent gains, triggering more than $440 million in leveraged position liquidations. Analysts view the pullback as a short-term hurdle in a broader recovery trend rather than a reversal.
goTop
quote